Investigating how physiologies & genomes evolve

Montooth Lab











Lab Publications

In Review:

Cooper, BS, Burrus, CR, Ji, C, Hahn, MW and KL Montooth. In Review. Similar efficacies of selection shape mitochondrial and nuclear genes in Drosophila melanogaster and Homo sapiens. bioRxiv


Cooper, BS, Hammad, LA, and KL Montooth. 2014. Thermal adaptation of cellular membranes in natural populations of Drosophila melanogaster. Functional Ecology 28:886-894. ARTICLE

Greenlee, KJ, Montooth, KL and BR Helm. 2014. Predicting performance and plasticity in the development of respiratory structures and metabolic systems. Integr Comp Biol 54:307-322. *co-first authors ARTICLE

Hoekstra, LA, Siddiq*, MA, and KL Montooth. 2013. Pleiotropic Effects of a Mitochondrial-Nuclear Incompatibility Depend Upon the Accelerating Effect of Temperature in DrosophilaGenetics 195:1129-1139. ARTICLE

Hoekstra, LA and KL Montooth. 2013. Inducing extra copies of the Hsp70 gene in Drosophila melanogaster increases energetic demand. BMC Evol Biol. 13:68. doi:10.1186/1471-2148-13-68. ARTICLE

Meiklejohn, CD, Holmbeck, MA, Siddiq*, MA, Abt, DN, Rand, DM and KL Montooth. 2013. An Incompatibility between a Mitochondrial tRNA and Its Nuclear-Encoded tRNA Synthetase Compromises Development and Fitness in Drosophila. PLoS Genet 9(1): e1003238. doi:10.1371/journal.pgen.1003238. ARTICLE

Kobey, RL and KL Montooth. 2013. Mortality from desiccation contributes to a genotype-by-temperature interaction for cold survival in Drosophila melanogaster. J Exp Biol. Published online Nov 29, 2012. ARTICLE

Cooper, BS, Hammad, LA, Fisher*, NP, Karty, JA and KL Montooth. 2012. In a variable thermal environment selection favors greater plasticity of cell membranes in Drosophila melanogaster. Evolution. doi: 10.1111/j.1558-5646.2011.01566.x ARTICLE

Hammad, LA, Cooper, BS, Fisher*, NP, Montooth, KL, and JA Karty. 2011. Profiling and quantification of Drosophila melanogaster lipids using liquid chromatography/mass spectrometry. Rapid Communications in Mass Spectrometry 25(19):2959-2968. ARTICLE

Montooth, KL, Meiklejohn, CD, Abt, DN and DM Rand. 2010. Mitochondrial-nuclear epistasis affects fitness within species but does not contribute to fixed incompatibilities between species of Drosophila. Evolution 64(12):3364-3379. *co-first authors ARTICLE

Montooth, KL, Abt, DN, Hofmann*, JW and DM Rand. 2009. Comparative genomics of Drosophila mtDNA:  novel features of conservation and change across functional domains and lineages.  J Mol Evol 69:94-114. ARTICLE

Montooth, KL and DM Rand. 2008. The Spectrum of Mitochondrial Mutation Differs across Species. PLoS Biol 6(8): e213 doi:10.1371/journal.pbio.0060213 ARTICLE


Other Publications by Members of the Lab

Condon, C, Cooper, BS, Yeaman, S, and MJ Angilletta. ACCEPTED. Temporal variation favors the evolution of generalists in experimental populations of Drosophila melanogaster. Evolution.

Czarnoleski M, Cooper, BS, Kierat, J, and MJ Angilletta. 2013. Flies developed small bodies and small cells in warm and in thermally fluctuating environments. J Exp Biol. 216:2896-2901.

Hoekstra LA, Moroz LL, A Heyland. 2012. Novel Insights into the Echinoderm Nervous System from Histaminergic and FMRFaminergic-Like Cells in the Sea Cucumber Leptosynapta clarki. PLoS ONE 7(9): e44220. doi:10.1371/journal.pone.0044220.

Lockwood, BL and GN Somero. 2013. Functional determinants of temperature adaptation in enzymes of cold- vs. warm-adapted mussels (genus Mytilus). Molecular Biology and Evolution. 29 (10):3061-3070. doi: 10.1093/molbev/mss111.

Cooper, BS, Tharp*, JM, Jernberg*, II, and MJ Angilletta. 2012. Developmental plasticity of thermal tolerances in temperate and subtropical populations of Drosophila melanogaster. J Therm Biol. http://dx.doi.org/10.1016/j.jtherbio.2012.01.001

Schuler, MS, Cooper, BS, Storm, JM, Sears, MW, and MJ Angilletta. 2011. Isopods failed to acclimate their thermal physiology of locomotor performance during predictable or stochastic cooling. PLoS ONE6(6): e20905. doi:10.1371/journal.pone.0020905.

Lockwood, BL and Somero, GN. 2011. Invasive and native blue mussels (genus Mytilus) on the California coast: the role of physiology in a biological invasion. Journal of Experimental Marine Biology and Ecology 400, 167-174.

Lockwood, BL and Somero, GN. 2011. Transcriptomic responses to salinity stress in invasive and native blue mussels (genus: Mytilus). Molecular Ecology 20, 517-529.

Cooper, BS, Czarnoleski, M, and MJ Angilletta. 2010. Acclimation of thermal physiology in natural populations of Drosophila melanogaster: a test of an optimality model. J Evol Biol 23: 2346-2355.

Angilletta, MJ, Cooper, BS, Schuler, MS, and JG Boyles. 2010. The evolution of thermal physiology in endotherms. Frontiers in Bioscience E2, 861-881.

Lockwood BL, Sanders, JG, and Somero, GN. 2010. Transcriptomic responses to acute heat stress in invasive and native blue mussels (genus: Mytilus): molecular correlates of invasive success. Journal of Experimental Biology 213, 3548-3558.

Denny, MW, Lockwood BL, and Somero, GN. 2009. Can the giant snake predict palaeoclimate? Nature 460, E3-E4.

Peng, J, Wagle, M, Mueller, T, Mathur, P, Lockwood BL, Bretaud, S, and Guo, S. 2009. Ethanol-modulated camouflage response screen in zebrafish uncovers a novel role for cAMP and extracellular signal-regulated kinase signaling in behavioral sensitivity to ethanol. Journal of Neuroscience 29, 8408-8418.

Cooper, BS, Williams*, BH, and MJ Angilletta. 2008. Unifying indices of heat tolerance in ectotherms. J Therm Biol 33: 320-323.

Bretaud, S, Li, Q, Lockwood, BL, Lau, B, Lin, E, and Guo, S. 2007. A choice behavior for morphine reveals experience-dependent drug preference and underlying neural substrates in developing larval zebrafish. Neuroscience 146, 1109-1116.

Folk, DG, Hoekstra, LA, and GW Gilchrist. 2007. Critical thermal maxima in knockdown-selected Drosophila: are thermal endpoints correlated? J Exp Biol 210, 2649-2656.

Drosophila 12 Genomes Consortium. 2007. Evolution of genes and genomes on the Drosophila phylogeny. Nature 450: 203-218. (contributed assembly, annotation and analysis of mtDNAs)

Meiklejohn, CD, Montooth, KL and DM Rand. 2007. Positive and negative selection on the mitochondrial genome.  Trends in Genetics 23(6): 259-263.

Montooth, KL, Siebenthall*, KT and AG Clark. 2006. Membrane lipid physiology and toxin catabolism underlie ethanol and acetic acid tolerance in Drosophila melanogaster. J Exp Biol 209: 3837-3850.

Zhang, M, Montooth, KL, Wells, MT, Clark, AG and D Zhang. 2005. Mapping multiple quantitative trait loci by Bayesian classification. Genetics 169(4): 2305-18.

Civetta, A, Montooth, KL and M Mendelson. 2005. Quantitative trait loci and interaction effects responsible for variation in female postmating mortality in Drosophila simulans and D. sechellia introgression lines. Heredity 94(1): 94-100.

Lockwood, BL, Bjerke, S, Kobayashi, K, and Guo, S. 2004. Acute effects of alcohol on larval zebrafish: a genetic system for large-scale screening. Pharmacology, Biochemistry and Behavior 77, 647-654.

Montooth, KL, Marden, JH and AG Clark. 2003.  Mapping determinants of variation in energy metabolism, respiration and flight in Drosophila. Genetics 165(2): 623-635.

Montooth, KL and AG Gibbs. 2003.  Cuticular pheromones and water balance in the house fly, Musca domestica. Comp Biochem Physiol A 135(3): 457-465.

Marden, JH, Rogina, B,  Montooth, KL and SL Helfand. 2003.  Conditional tradeoffs between aging and organismal performance of Indy long-lived mutant flies. PNAS 100(6): 3369-3373.

* indicates undergraduates who have collaborated on this research