Lab Publications
Li, H, Buddika, K, Sterrett, MC, Julick, CR, Pletcher, RC, Gosney, CJ, Burton, AK, Karty, JA, Montooth, KL, Sokol, NS, and JM Tennessen. 2019. Lactate and glycerol-3-phosphate metabolism cooperatively regulate growth and redox balance during Drosophila melanogaster larval development. BioRxiv 517532 ARTICLE
Matoo, O, Julick, CR, and KL Montooth. 2018. Genetic variation for ontogenetic shifts in metabolism underlies physiological homeostasis at the mitochondrial and organismal levels. BioRxiv 456269 ARTICLE
Buchanan, JL, Meiklejohn, CD, and KL Montooth. 2018. Metabolic dysfunction and infection generate immunity-fecundity tradeoffs in Drosophila. Integrative and Comparative Biology, Integr Comp Biol 58, 591–603 ARTICLE
Hood, WR, Austad, SN, Bize, P, Jimenez, AG, Montooth, KL, Schulte, PM, Scott, GR, Sokolova, I, Treberg, JR, and K Salin. 2018. The mitochondrial contribution to animal performance, adaptation, and life-history variation. Integr Comp Biol 58, 580–585 ARTICLE
DeLong, JP, Bachman, G, Gibert, JP, Luhring, TM, Montooth, KL, Neyer, A, and B Reed. 2018 Habitat, latitude, and body mass influence the temperature dependence of metabolic rate. Biology Letters 20180442. ARTICLE
Hoekstra, LA, Julick, CR, Mika, KM, and KL Montooth. 2018 Energy demand and the context-dependent effects of genetic interactions underlying metabolism. Evolution Letters 2:102-113 ARTICLE
Lockwood, BL, Julick, CR, and KL Montooth. 2017 Maternal loading of a small heat shock protein increases embryo thermal tolerance in Drosophila melanogaster. J Exp Biol 220: 4492-4501 ARTICLE PREPRINT
Zhang, C, Montooth, KL, and BR Calvi. 2017 Incompatibility between mitochondrial and nuclear genomes during oogenesis results in ovarian failure and embryonic lethality. Development 144: 2490-2503 ARTICLE
DeLong, JP, Gibert, JP, Luhring, TM, Bachman, G, Reed, B, Neyer, A, and KL Montooth. 2017 The combined effects of reactant kinetics and enzyme stability explain the temperature dependence of metabolic rates. Ecology & Evolution, DOI: 10.1002/ece3.2955 ARTICLE
Siddiq, MA, Loehlin, DW, Montooth, KL and JW Thornton. 2017 Experimental test and refutation of a classic case of molecular adaptation in Drosophila melanogaster. Nature Ecol Evol 1, 0025 ARTICLE
Adrion, JR, White, PS, and KL Montooth. 2016 The roles of compensatory evolution and constraint in aminoacyl tRNA synthetase evolution. Mol Biol Evol, 33: 152-161 ARTICLE
Cooper, BS, Burrus, C, Ji, C, Hahn, MW and KL Montooth. 2015 Similar efficacies of selection shape mitochondrial and nuclear genes in both Drosophila melanogaster and Homo sapiens. G3 5: 2165-2176 ARTICLE
Cooper, BS, Hammad, LA, and KL Montooth. 2014. Thermal adaptation of cellular membranes in natural populations of Drosophila melanogaster. Functional Ecology 28:886-894. ARTICLE
Greenlee (1), KJ, Montooth (1), KL and BR Helm. 2014. Predicting performance and plasticity in the development of respiratory structures and metabolic systems. Integr Comp Biol 54:307-322. *co-first authors ARTICLE
Hoekstra, LA, Siddiq*, MA, and KL Montooth. 2013. Pleiotropic Effects of a Mitochondrial-Nuclear Incompatibility Depend Upon the Accelerating Effect of Temperature in Drosophila. Genetics 195:1129-1139. ARTICLE
Hoekstra, LA and KL Montooth. 2013. Inducing extra copies of the Hsp70 gene in Drosophila melanogaster increases energetic demand. BMC Evol Biol. 13:68. doi:10.1186/1471-2148-13-68. ARTICLE
Meiklejohn, CD, Holmbeck, MA, Siddiq*, MA, Abt, DN, Rand, DM and KL Montooth. 2013. An Incompatibility between a Mitochondrial tRNA and Its Nuclear-Encoded tRNA Synthetase Compromises Development and Fitness in Drosophila. PLoS Genet 9(1): e1003238. doi:10.1371/journal.pgen.1003238. ARTICLE
Kobey, RL and KL Montooth. 2013. Mortality from desiccation contributes to a genotype-by-temperature interaction for cold survival in Drosophila melanogaster. J Exp Biol. Published online Nov 29, 2012. ARTICLE
Cooper, BS, Hammad, LA, Fisher*, NP, Karty, JA and KL Montooth. 2012. In a variable thermal environment selection favors greater plasticity of cell membranes in Drosophila melanogaster. Evolution. doi: 10.1111/j.1558-5646.2011.01566.x ARTICLE
Hammad, LA, Cooper, BS, Fisher*, NP, Montooth, KL, and JA Karty. 2011. Profiling and quantification of Drosophila melanogaster lipids using liquid chromatography/mass spectrometry. Rapid Communications in Mass Spectrometry 25(19):2959-2968. ARTICLE
Montooth (1), KL, Meiklejohn (1), CD, Abt, DN and DM Rand. 2010. Mitochondrial-nuclear epistasis affects fitness within species but does not contribute to fixed incompatibilities between species of Drosophila. Evolution 64(12):3364-3379. (1) co-first authors ARTICLE
Montooth, KL, Abt, DN, Hofmann*, JW and DM Rand. 2009.Comparative genomics of Drosophila mtDNA: novel features of conservation and change across functional domains and lineages. J Mol Evol 69:94-114. ARTICLE
Montooth, KL and DM Rand. 2008. The Spectrum of Mitochondrial Mutation Differs across Species. PLoS Biol 6(8): e213 doi:10.1371/journal.pbio.0060213 ARTICLE
Matoo, O, Julick, CR, and KL Montooth. 2018. Genetic variation for ontogenetic shifts in metabolism underlies physiological homeostasis at the mitochondrial and organismal levels. BioRxiv 456269 ARTICLE
Buchanan, JL, Meiklejohn, CD, and KL Montooth. 2018. Metabolic dysfunction and infection generate immunity-fecundity tradeoffs in Drosophila. Integrative and Comparative Biology, Integr Comp Biol 58, 591–603 ARTICLE
Hood, WR, Austad, SN, Bize, P, Jimenez, AG, Montooth, KL, Schulte, PM, Scott, GR, Sokolova, I, Treberg, JR, and K Salin. 2018. The mitochondrial contribution to animal performance, adaptation, and life-history variation. Integr Comp Biol 58, 580–585 ARTICLE
DeLong, JP, Bachman, G, Gibert, JP, Luhring, TM, Montooth, KL, Neyer, A, and B Reed. 2018 Habitat, latitude, and body mass influence the temperature dependence of metabolic rate. Biology Letters 20180442. ARTICLE
Hoekstra, LA, Julick, CR, Mika, KM, and KL Montooth. 2018 Energy demand and the context-dependent effects of genetic interactions underlying metabolism. Evolution Letters 2:102-113 ARTICLE
Lockwood, BL, Julick, CR, and KL Montooth. 2017 Maternal loading of a small heat shock protein increases embryo thermal tolerance in Drosophila melanogaster. J Exp Biol 220: 4492-4501 ARTICLE PREPRINT
Zhang, C, Montooth, KL, and BR Calvi. 2017 Incompatibility between mitochondrial and nuclear genomes during oogenesis results in ovarian failure and embryonic lethality. Development 144: 2490-2503 ARTICLE
DeLong, JP, Gibert, JP, Luhring, TM, Bachman, G, Reed, B, Neyer, A, and KL Montooth. 2017 The combined effects of reactant kinetics and enzyme stability explain the temperature dependence of metabolic rates. Ecology & Evolution, DOI: 10.1002/ece3.2955 ARTICLE
Siddiq, MA, Loehlin, DW, Montooth, KL and JW Thornton. 2017 Experimental test and refutation of a classic case of molecular adaptation in Drosophila melanogaster. Nature Ecol Evol 1, 0025 ARTICLE
Adrion, JR, White, PS, and KL Montooth. 2016 The roles of compensatory evolution and constraint in aminoacyl tRNA synthetase evolution. Mol Biol Evol, 33: 152-161 ARTICLE
Cooper, BS, Burrus, C, Ji, C, Hahn, MW and KL Montooth. 2015 Similar efficacies of selection shape mitochondrial and nuclear genes in both Drosophila melanogaster and Homo sapiens. G3 5: 2165-2176 ARTICLE
Cooper, BS, Hammad, LA, and KL Montooth. 2014. Thermal adaptation of cellular membranes in natural populations of Drosophila melanogaster. Functional Ecology 28:886-894. ARTICLE
Greenlee (1), KJ, Montooth (1), KL and BR Helm. 2014. Predicting performance and plasticity in the development of respiratory structures and metabolic systems. Integr Comp Biol 54:307-322. *co-first authors ARTICLE
Hoekstra, LA, Siddiq*, MA, and KL Montooth. 2013. Pleiotropic Effects of a Mitochondrial-Nuclear Incompatibility Depend Upon the Accelerating Effect of Temperature in Drosophila. Genetics 195:1129-1139. ARTICLE
Hoekstra, LA and KL Montooth. 2013. Inducing extra copies of the Hsp70 gene in Drosophila melanogaster increases energetic demand. BMC Evol Biol. 13:68. doi:10.1186/1471-2148-13-68. ARTICLE
Meiklejohn, CD, Holmbeck, MA, Siddiq*, MA, Abt, DN, Rand, DM and KL Montooth. 2013. An Incompatibility between a Mitochondrial tRNA and Its Nuclear-Encoded tRNA Synthetase Compromises Development and Fitness in Drosophila. PLoS Genet 9(1): e1003238. doi:10.1371/journal.pgen.1003238. ARTICLE
Kobey, RL and KL Montooth. 2013. Mortality from desiccation contributes to a genotype-by-temperature interaction for cold survival in Drosophila melanogaster. J Exp Biol. Published online Nov 29, 2012. ARTICLE
Cooper, BS, Hammad, LA, Fisher*, NP, Karty, JA and KL Montooth. 2012. In a variable thermal environment selection favors greater plasticity of cell membranes in Drosophila melanogaster. Evolution. doi: 10.1111/j.1558-5646.2011.01566.x ARTICLE
Hammad, LA, Cooper, BS, Fisher*, NP, Montooth, KL, and JA Karty. 2011. Profiling and quantification of Drosophila melanogaster lipids using liquid chromatography/mass spectrometry. Rapid Communications in Mass Spectrometry 25(19):2959-2968. ARTICLE
Montooth (1), KL, Meiklejohn (1), CD, Abt, DN and DM Rand. 2010. Mitochondrial-nuclear epistasis affects fitness within species but does not contribute to fixed incompatibilities between species of Drosophila. Evolution 64(12):3364-3379. (1) co-first authors ARTICLE
Montooth, KL, Abt, DN, Hofmann*, JW and DM Rand. 2009.Comparative genomics of Drosophila mtDNA: novel features of conservation and change across functional domains and lineages. J Mol Evol 69:94-114. ARTICLE
Montooth, KL and DM Rand. 2008. The Spectrum of Mitochondrial Mutation Differs across Species. PLoS Biol 6(8): e213 doi:10.1371/journal.pbio.0060213 ARTICLE
Earlier Publications:
Drosophila 12 Genomes Consortium. 2007. Evolution of genes and genomes on the Drosophila phylogeny. Nature 450: 203-218. (contributed assembly, annotation and analysis of mtDNAs)
Meiklejohn, CD, Montooth, KL and DM Rand. 2007. Positive and negative selection on the mitochondrial genome. Trends in Genetics 23(6): 259-263.
Montooth, KL, Siebenthall*, KT and AG Clark. 2006. Membrane lipid physiology and toxin catabolism underlie ethanol and acetic acid tolerance in Drosophila melanogaster. J Exp Biol 209: 3837-3850.
Zhang, M, Montooth, KL, Wells, MT, Clark, AG and D Zhang. 2005. Mapping multiple quantitative trait loci by Bayesian classification. Genetics 169(4): 2305-18.
Civetta, A, Montooth, KL and M Mendelson. 2005. Quantitative trait loci and interaction effects responsible for variation in female postmating mortality in Drosophila simulans and D. sechellia introgression lines. Heredity 94(1): 94-100.
Montooth, KL, Marden, JH and AG Clark. 2003. Mapping determinants of variation in energy metabolism, respiration and flight in Drosophila. Genetics 165(2): 623-635.
Montooth, KL and AG Gibbs. 2003. Cuticular pheromones and water balance in the house fly, Musca domestica. Comp Biochem Physiol A 135(3): 457-465.
Marden, JH, Rogina, B, Montooth, KL and SL Helfand. 2003. Conditional tradeoffs between aging and organismal performance of Indylong-lived mutant flies. PNAS 100(6): 3369-3373.
* indicates undergraduates who have collaborated on this research
Meiklejohn, CD, Montooth, KL and DM Rand. 2007. Positive and negative selection on the mitochondrial genome. Trends in Genetics 23(6): 259-263.
Montooth, KL, Siebenthall*, KT and AG Clark. 2006. Membrane lipid physiology and toxin catabolism underlie ethanol and acetic acid tolerance in Drosophila melanogaster. J Exp Biol 209: 3837-3850.
Zhang, M, Montooth, KL, Wells, MT, Clark, AG and D Zhang. 2005. Mapping multiple quantitative trait loci by Bayesian classification. Genetics 169(4): 2305-18.
Civetta, A, Montooth, KL and M Mendelson. 2005. Quantitative trait loci and interaction effects responsible for variation in female postmating mortality in Drosophila simulans and D. sechellia introgression lines. Heredity 94(1): 94-100.
Montooth, KL, Marden, JH and AG Clark. 2003. Mapping determinants of variation in energy metabolism, respiration and flight in Drosophila. Genetics 165(2): 623-635.
Montooth, KL and AG Gibbs. 2003. Cuticular pheromones and water balance in the house fly, Musca domestica. Comp Biochem Physiol A 135(3): 457-465.
Marden, JH, Rogina, B, Montooth, KL and SL Helfand. 2003. Conditional tradeoffs between aging and organismal performance of Indylong-lived mutant flies. PNAS 100(6): 3369-3373.
* indicates undergraduates who have collaborated on this research
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